Human Sera
Cayman Chemical ElIptIcInhydrochlorIde 50mg
An agonist of human CAR (EC50 49 nM) induces nuclear translocation of human CAR in hepatocytes followed by increased expression of CAR-regulated genes
Cayman Chemical Nacetyl Sulfamethoxazole 100mg
An inhibitor of MEK1 and -2 inhibits B-RAF- and C-RAF-induced phosphorylation of MEK1 (IC50s 3.4 and 1.8 nM respectively) and MEK2 (IC50s 1.6 and 0.92 nM respectively) inhibits the growth of two human colorectal cancer cell lines expressing mutant B-RAF (IC50s 0.48 and 0.52 nM) and seven cell lines expressing mutant K-Ras (IC50s 2.2-174 nM) but does not inhibit the growth of wild-type COLO 320DM cells expressing both B-RAF and K-Ras (IC50 10000 nM) reduces tumor growth in HT-29 and COLO 205 mouse xenograft models at 0.3 and 1 mg/kg per day decreases M. tuberculosis-induced increases in hind paw volume in a rat model of arthritis at 0.03 and 0.1 mg/kg per day
Cayman Chemical AceclIdInhydrochlorIde 100mg
A carbapenem antibiotic active against clinical isolates of Gram-positive and Gram-negative bacteria in vitro including S. pneumoniae H. influenzae N. gonorrhoeae E. coli P. aeruginosa C. difficile and methicillin-susceptible and -resistant S. aureus (MICs ≤0.008-8 g/ml) protective against S. aureus S. pneumoniae E. coli S. marcescens P. mirabilis and P. aeruginosa infections in mice (PD50s 0.13 0.01 0.04 0.07 0.84 and 0.46 mg/kg respectively)
Cayman Chemical ThIocolchIcIn 100mg
An allosteric activator of CD11b/CD18 increases K562 cell adhesion to fibrinogen (EC50 4 UM) reduces rolling velocity of leukocytes decreasing the number of leukocytes recruited to injured tissue anti-inflammatory in a zebrafish tailfin injury model and a mouse model of nephritis competitively inhibits YopH (Ki 1.94 UM) and anthrax lethal factor metalloproteinase (IC50 6 UM)
Cayman Chemical SB-224289hydrochlorIde 50mg
A derivative of NNEI that has a chloride atom added to the terminal carbon of the pentyl group intended for forensic and research applications
Cayman Chemical 3BromomethcathInonhydroch 50mg
A selective reversible inhibitor of autotaxin completely blocking the hydrolysis of the substrate bis-pNPP with an IC50 value of 28 nM rapidly decreases plasma lysophosphatidic acid levels in mice when given intravenously (1 nM/g)
Cayman Chemical 4methoxyaPyrroldInopentIo 50mg
A natural 200 ceramide that is abundant in the brain synthesized de novo by ceramide synthases 1 and 2
Cayman Chemical FatostatInhydrobromIde 50mg
An imidazole that has potent antibacterial properties in drug-resistant bacteria in bacteria inhibits several histidine kinases inhibiting YycG with IC50 values ranging from 0 7-4 7 UM decreases viability of several cancer cell lines with IC50 values ranging from 0 7-4 7 UM
Cayman Chemical 2amIno PyrIdyl5thIoamIde 100mg
A dual inhibitor of class I PI3Ks and mTOR (IC50s 4 75 7 and 5 nM for p110a - B - and -Y respectively) and mTOR (IC50 20 nM) selective for these enzymes over a panel of kinases (IC50s 10 UM for all) inhibits proliferation of and induces apoptosis in MCF-7 MDA-MB-468 SK-BR-3 and MDA-MB-361 breast cancer cells at 0 1 or 1 UM reduces tumor growth in a U87MG mouse xenograft model at 25 35 or 45 mg/kg
Cayman Chemical IrInotecnhydroCLOrID hyd 100mg
Potent HDAC6 inhibitor (IC50 15 nM) with 1000-fold selectivity against all other HDAC isoforms (IC50s 16 M) excluding HDAC8 (IC50 0 9 M) induces a-tubulin hyperacetylation at 2 5 M in primary cortical neuron cultures displays dose-dependent neuronal protection of primary cortical neuron cultures at 5-10 M
Cayman Chemical trns-ZeatIn 50mg
mmunogen Peptde from an nternal cytoplasmc regon of human S1P1 Host Rabbt Speces Reactvty ( ) Human mouse porcne and rat S1P1 Applcaton(s) F HC and WB S1P exerts ts actvty by bndng to fve dstnct GPCRs S1P1/EDG1 S1P2/EDG5 S1P3/EDG3 S1P4/EDG6 and S1P5/EDG8 S1P1 prmarly medates S1Pnduced cell prolferaton survval mgraton cytoskeletal organzaton and morphogeness Expresson of S1P1 s abundant n embryologcal vasculature and s ubqutously expressed n adult cells suggestng dverse physologcal functons of ths receptor
Cayman Chemical PterostIlben 100mg
A selectve PLA2B nhbtor nhbts vasopressn-nduced release of arachdonate from cultured rat aortc smooth muscle (A10) cells (C50 2 UM) 1000-fold selectve for PLA2 versus cPLA2 and 10-fold selectve for PLA2B versus PLA2Y
Cayman Chemical 4-HydroxyIsoleucIn 100mg
An HMG-CoA reductase inhibitor (Ki 0 1 UM) inhibits cholesterogenesis in the liver and ileum of normolipidemic rats as well as enhances suppression of cholesterogenesis in cholesterol-fed rats or rats administered cholestyramine at 50 mg/kg suppresses TNF-induced NF-KB activation (IC50 17 UM) and potentiates apoptosis in human myeloid leukemia cells suppresses induced ferroptosis in HT-1080 cells
Cayman Chemical STetrahydrofurn2ylmeth 50mg
A sodium channel blocker with high-affinity and selectivity for inhibiting human Nav1 8 sodium channels (IC50 8 nM when stimulated at half-maximal inactivation and IC50 79 nM at a resting state) dose dependently reduces behavioral responses in a variety of neuropathic and inflammatory pain models