Human Sera
Cayman Chemical 5Deoxy5methylthIoadenosI 100mg
An intermediate in the generation of adenine and methionine that is produced by the decarboxylation of SAM; a potent agonist of adenosine receptors (Kis = 0.15, 1.13, 13.9, and 0.68 μM for A1, A2A, A2B, and A3, respectively); inhibits several enzymes at higher concentrations
Cayman Chemical RIstocetIn Asulfate 50mg
An antibiotic used in the ristocetin cofactor assay and the ristocetin-induced platelet aggregation assay, for the diagnosis of von Willebrand disease and other bleeding disorders
Cayman Chemical CID-2818500 50mg
An inhibitor of PRMT1 (IC50 = 11 μM in a histone H4 methylation assay); inhibits histone H4 methylation by PRMT8, but not histone H3.1 methylation by CARM1 or Set7/9, at 10 and 100 μM
Cayman Chemical DImaprIthydrochlorIde 100mg
A histamine H2 receptor agonist (Ki = 44 µM in guinea pig right atrium); selectively stimulates H2 over H1 and H3 receptors with relative potencies of 71, A. suum extract, which is not affected by pretreatment with mepyramine or cimetidine; stimulates gastric acid secretion in vivo in anaesthetized rats and cats with relative potencies of 19.5 and approximately 400 to 500, respectively, compared to histamine; inhibits 2-(2-pyridyl)ethylamine-induced bronchoconstriction in guinea pigs in a dose-dependent manner
Cayman Chemical IrsogladInmaleate 50mg
A gastroprotective agent; increases transfer of Lucifer yellow CH between isolated rabbit gastric epithelial cells, indicating enhanced GJIC; inhibits gastric mucosal lesion formation and decreases in gastric mucosal blood flow induced by monochloramine in rats at 3 mg/kg, effects that can be prevented by L-NAME; inhibits fMLP-induced superoxide anion production and increases cAMP levels in isolated human neutrophils in a concentration-dependent manner, similar to rolipram
Cayman Chemical FlecaInIdeacetate 50mg
An inhibitor of cardiac late INa channels (IC50 = 3.4 µM) and IKr channels (IC50 = 1.5 µM); used clinically to suppress arrhythmias and sodium-dependent calcium overload associated with myocardial ischemia and heart failure
Cayman Chemical N1AcetylspermInhydrochLR 50mg
A monoacetylated derivative of spermine (Item No. 18041), an endogenous polyamine synthesized from spermidine (Item No. 14918), that displays lower Km and higher Vmax values than spermine, making it a better substrate of polyamine oxidase than the non-acetylated polyamine
Cayman Chemical PyrIdoal IsonIcotInyl hyd 50mg
A lipophilic, nontoxic, iron-chelating agent that shows high iron chelation efficacy both in vitro in cell culture models and also in vivo in rats and mice
Cayman Chemical TAS 103hydrochlorIde 100mg
A DNA topoisomerase I and II inhibitor (IC50s = 2 and 6.5 µM, respectively); stabilizes topoisomerase I-DNA and topoisomerase II-DNA cleavable complexes in KB cells at 3 µM; cytotoxic to P388 and KB cells (IC50s = 1.1 and 9.6 nM, respectively); reduces pulmonary metastasis in murine B16-BL6 melanoma and UV-2237M fibrosarcoma models of lung metastasis at 15, 26, and 45 mg/kg per day; reduces tumor growth in a variety of human cancer mouse xenograft models
Cayman Chemical IrsogladInmaleate 100mg
A gastroprotective agent; increases transfer of Lucifer yellow CH between isolated rabbit gastric epithelial cells, indicating enhanced GJIC; inhibits gastric mucosal lesion formation and decreases in gastric mucosal blood flow induced by monochloramine in rats at 3 mg/kg, effects that can be prevented by L-NAME; inhibits fMLP-induced superoxide anion production and increases cAMP levels in isolated human neutrophils in a concentration-dependent manner, similar to rolipram
Cayman Chemical BIlIverdInhydrochlorIde 100mg
A green bile pigment produced from the oxidation of heme in a reaction catalyzed by heme oxygenase and further reduced to bilirubin by biliverdin reductase; possesses anti-mutagenic and antioxidant properties, scavenging free radicals
Cayman Chemical In vItro Screeng for DrugI 96
A RIPK1 inhibitor (IC50s 16 and 2500 nM for the human and mouse enzymes respectively) 10000-fold selective for RIPK1 over a panel of 339 kinases at 10 UM inhibits necrotic cell death induced by a combination of TNF-a and the caspase inhibitor QVD-OPh in U937 human monocytic and L929 murine fibrosarcoma cells (IC50s 6 3 and 1300 nM respectively) decreases IL-1B and IL-6 levels in intestinal mucosa tissue isolated from patients with ulcerative colitis at 3-300 nM increases survival in a mouse model of TNF-a-induced lethal shock at 3 10 and 50 mg/kg
Cayman Chemical 1MethylhIstamInhydroCLOr 100mg
A major metabolite of histamine used as a biomarker of histaminergic system activity via CSF levels in Alzheimer’s disease patients
Cayman Chemical ZINC00881524 50mg
A ROCK inhibitor; decreases levels of ROCK1 in T47D and CAMA-1 breast cancer cells; decreases proliferation of T47D and CAMA-1 cells when used in combination with CNN1 knockdown